Generic Flutamide (Eulexin) Mexico
A non-steroidal anti-inflammatory drug that blocks androgen receptors in tissues The active substance prevents testosterone from binding and affecting cells. It is prescribed to influence cancer cells and metastases that increase their growth in testicles.
Release form, composition, and packaging
Flutamide is available in tablet form. The product is yellow in color and has a round configuration. The main active material is the compound flutamide. Auxiliary chemical components include silicon dioxide, microcrystalline cellulose, magnesium stearate, lactose monohydrate, and other compounds. The pills are placed in blisters of 10 pieces.
Pharmacologic Effect
The active component belongs to acetanilides. As a non-steroidal oral antiandrogen, it blocks the connection with male hormones, preventing them from binding to the nuclear intercellular substance in target tissues. The result is a decrease in adrenal activity. It’s characterized by its antitumor quality. Prevents the interaction of androgens with the receptors of their cellular organizations. The mechanism of influence is characterized by slowing down androgen uptake. The drug has the ability to resist the effects of testosterone. A pharmaceutical product is not characterized by estrogenic, antiestrogenic, or progestogenic effects on the body systems.
Flutamide is rapidly absorbed after oral administration. The maximum saturation of the active derivative of hydroxyflutamide occurs after 2 hours. The half-life is 6 hours. About 96% of the starting material and 94% of the derivative are bound to plasma proteins. During the first two days after administration, about half of the substance is removed along with urine and 2% with feces through the digestive tract.
Indications for Use and Contraindications
The medicine is prescribed in the case of the diagnosis of a primary or metastatic form of a malignant prostate tumor or together with luteinizing gonadotropin-releasing hormone agonists. The drug is also prescribed when undergoing combined treatment for local prostate cancer to suppress the development of tumors and increase the interval between relapses. Doctors prescribe pharmaceutical products to people with surgical castrations when certain types of hormonal materials have not shown results.
The use of flutamide is not allowed in cases of hypersensitivity to the active ingredient and severe dysfunction of the hepatobiliary structure. Liver failure as well as a high probability of developing thrombosis and pathologies of the heart and blood vessels are the main reasons why the medication should not be used.
Special Instructions and Dosage
Therapeutic procedures are carried out by monitoring the functioning of liver enzymes in the serum of the blood substance. If the activity of liver enzymes has increased several times in comparison with the ULN or jaundice develops without metastases in the organ, the use of pharmaceutical products should be stopped immediately. The patient should be aware of the possible manifestations of painful symptoms while using the medication. If skin itching, gag reflexes, darkening of urine, changes in skin color, pain in the right hypochondrium, or other signs reminiscent of the development of the flu occur, a person should immediately consult a doctor. If the patient has not undergone surgical castration, the process of spermatogenesis is monitored during long-term therapeutic exposure to the substance. According to medical reviews, the use of the flutamide compound leads to an increase in the levels of estradiol and testosterone in the blood. Because of this, water may be retained in the systems. The drug is prescribed with care for the development of diseases of the heart and blood vessels and for people prone to swelling.
According to the instructions, driving vehicles and other complex technical equipment during therapy with the introduction of antiandrogenic materials are contraindicated. This is due to the development of collateral symptoms in the form of vertigo, increased drowsiness, visual perception disorders, and high fatigue.
The drug is taken orally at 250 mg three times every 24 hours. The procedure is carried out every 8 hours. The substance is used when a positive result is obtained before symptoms of cancer progression occur.
Side effects
A frequent incident occurring while taking flutamide is hardening of the mammary glands, which is accompanied by spontaneous secretion of lactose, regardless of the patient’s gender. It is reversible and disappears after discontinuation of the drug or dosage adjustment. Additionally, complications arise from: