Generic Antabuse (Disulfiram)

Common Use
Antabuse is a medication used in the treatment of chronic alcoholism. It contains the active ingredient disulfiram, which works by blocking the enzyme alcohol dehydrogenase (ADH) involved in ethanol metabolism. This causes a buildup of acetaldehyde, resulting in unpleasant symptoms such as:

• Flushing

• Nausea and vomiting

• Headache

• Tachycardia (rapid heartbeat)

• Low blood pressure
  These symptoms deter patients from consuming alcohol during treatment.

Dosage and Administration

• Take Antabuse orally with a full glass of water, at least 12 hours after your last alcoholic drink.

• Avoid all forms of alcohol while taking Antabuse, including:

  • Beer, wine, and spirits

  • Alcohol-containing products like aftershave, cologne, mouthwash, liquid medications

Precautions
Before using Antabuse, notify your doctor if you:

• Have a history of cardiovascular disease, ulcers, or cerebral circulation disorders

• Experienced disulfiram-induced psychosis

• Are over 60 years old, as caution is advised in this age group

Contraindications
Do not use Antabuse if you have any of the following conditions:

• Severe heart or vascular diseases

• Optic neuritis or glaucoma

• Bronchial asthma, emphysema, or pulmonary tuberculosis

• Severe liver disease or kidney disease

• Mental illness, psychosis, or seizures

• Peptic ulcers

• Diabetes or hyperthyroidism

• Polyneuritis or malignant tumors

• Pregnancy or breastfeeding

• Allergy to disulfiram or any inactive ingredients

Possible Side Effects

Common side effects may include:

• Drowsiness

• Headache

• Restlessness

• Acne or skin rash

• Changes in vision

• Garlic-like or metallic aftertaste

Serious side effects include:

• Tingling or numbness in hands/feet

• Severe stomach pain, nausea, vomiting

• Loss of appetite or fatigue

• Dark urine or yellowing of skin/eyes (signs of liver damage)
  Seek medical help if serious or persistent symptoms occur.

Drug Interactions
Inform your doctor if you are taking any of the following:

• Tricyclic antidepressants (e.g., amitriptyline, imipramine)

• MAO inhibitors (e.g., phenelzine, isocarboxazid)

• Anticonvulsants (e.g., phenytoin)

• Antibiotics (e.g., metronidazole)

• Anticoagulants (e.g., warfarin)

• Theophylline

• Benzodiazepines (e.g., diazepam, alprazolam)

• Lithium
  Some combinations may cause serious side effects or require dosage adjustments.

Missed Dose

• Take as soon as you remember unless it’s almost time for your next dose.

• Do not double up to make up for a missed dose.

Overdose
Seek emergency medical attention immediately.
Symptoms may include:

• Loss of coordination

• Severe nausea and vomiting

• Dizziness

• Numbness or tingling

• Seizures

Storage

• Store at room temperature between 59–86°F (15–30°C)

• Keep away from light, moisture, and heat

• Do not store in the bathroom

• Keep away from children and pets

Disclaimer
This summary provides general information and does not replace professional medical advice. Do not use this medication without consulting a licensed physician. This information may not cover all possible uses, interactions, or side effects. We assume no responsibility for misuse, self-treatment, or adverse outcomes resulting from reliance on this information.