Generic Glucotrol (Glipizide)

Common Use
Glipizide is an oral medication from the sulfonylurea class used to treat type 2 diabetes. It helps lower blood sugar by stimulating the pancreas to release insulin. Other drugs in this class include glimepiride (Amaryl), glyburide (Micronase, Diabeta), tolbutamide (Orinase), and tolazamide (Tolinase).

Dosage and Administration
Do not change your dose of Glipizide without first consulting your doctor.

• Immediate-release tablets: The typical starting dose is 5 mg, taken 30 minutes before a meal. The maximum daily dose is 40 mg.

• Extended-release tablets: The maximum dose should not exceed 20 mg per day.
  Take the tablet with a full glass of water before meals. For best results, take Glipizide consistently at the same time each day.

Precautions
Glipizide may increase the risk of cardiovascular death. Avoid alcohol, as it may lower your blood sugar unpredictably. Do not chew, crush, or split extended-release tablets; swallow them whole. Monitor your blood sugar regularly and inform your doctor of any symptoms or changes in your health.

Contraindications
Do not use Glipizide if you have:

• Known hypersensitivity to the drug

• Type 1 diabetes (insulin-dependent)

• Diabetic ketoacidosis or coma

• Severe kidney or liver dysfunction

• Gastrointestinal tract narrowing or blockage

• Infants should not be given this medication

Side Effects
Common side effects may include:

• Headache, dizziness

• Diarrhea, gas

• Low sodium levels

• Symptoms of liver issues such as jaundice or hepatitis

Serious allergic reactions may involve:

• Rash, hives, swelling of the face, lips, tongue, or throat
  Seek immediate medical attention if you experience signs of an allergic reaction.

Drug Interactions
Alcohol can delay Glipizide’s effects by slowing its absorption. Take Glipizide 1–2 hours before cholestyramine. Other medications may enhance or reduce Glipizide’s effects:

• Increase effect: Fluconazole, aspirin, NSAIDs, sulfa drugs, MAO inhibitors, beta-blockers, and more

• Reduce effect: Thiazide diuretics, corticosteroids (e.g., prednisone), estrogens, thyroid medications, phenytoin, niacin, calcium channel blockers

Always inform your healthcare provider of all medications and supplements you’re taking.

Missed Dose
If you miss a dose, take it as soon as you remember unless it is close to your next scheduled dose. Do not take extra doses to make up for a missed one. Resume your regular dosing schedule with your next dose.

Overdose
Symptoms of overdose include signs of low blood sugar such as:

• Sweating, anxiety, drowsiness

• Hunger, nausea, cold sweats

• Weakness, confusion, or loss of consciousness
  Seek emergency medical help immediately if overdose is suspected.

Storage
Store at room temperature (20–25°C / 68–77°F) away from moisture, heat, and direct sunlight. Do not store in a bathroom. Keep out of reach of children and pets.

Disclaimer
This information is for general knowledge and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your doctor or pharmacist for guidance specific to your health condition. We do not accept liability for the accuracy of this content or any harm resulting from its use.