Generic Lozol (Indapamide)

Common Use
Lozol is a thiazide-like diuretic used to treat high blood pressure (hypertension), either alone or in combination with other antihypertensive agents. Its active substance is Indapamide, a benzamide-sulfonamide-indole compound. It works by altering sodium reabsorption in the loop of Henle in the kidneys, increasing the excretion of sodium (Na⁺), chloride (Cl⁻), potassium (K⁺), and magnesium (Mg²⁺). Lozol requires long-term use to be effective; the therapeutic effect typically begins within 1–2 weeks, peaks by 8–12 weeks, and may persist for up to 8 weeks after stopping the medication.

Dosage and Administration

• Take once daily, preferably in the morning before breakfast, with or without food.

• The usual starting dose is 1.25 mg per day, which may be increased up to 5 mg daily if needed.

• Always follow your doctor’s instructions exactly.

Precautions
Lozol can lead to significant loss of electrolytes, particularly potassium, especially in elderly women.
Signs of low potassium (hypokalemia) include:

• Muscle weakness

• Irregular or rapid heartbeat

To compensate, your doctor may recommend potassium-rich foods or supplements.
Risk factors for hypokalemia include:

• High doses of Lozol

• Cirrhosis

• Use of corticosteroids or ACTH

Regular monitoring is advised for:

• Blood pressure

• Serum potassium, sodium, magnesium

• Glucose, uric acid, and kidney function tests

Extra care is needed for people with:

• Gout or hyperuricemia

• Liver or kidney disease

• Diabetes

• Systemic lupus erythematosus (SLE)

Contraindications
Do not use Lozol if you have:

• Allergy to Indapamide or related compounds

• Severe liver or kidney failure (anuria)

• Low potassium levels (hypokalemia)

• Lactose intolerance, galactosemia, or glucose malabsorption syndromes (if the product contains lactose)

• Cerebrovascular accident with edema

• Decompensated diabetes with ketoacidosis

Use caution if you have:

• Water-electrolyte imbalance

• Moderate liver/kidney dysfunction

• Ascites

• Coronary artery disease or heart failure

• Hyperparathyroidism

• Hyperuricemia (gout)

• Are pregnant, breastfeeding, elderly, or under 18 years of age

Possible Side Effects
Side effects depend on dosage and may include:

• Dizziness, headache, back pain

• Agitation, anxiety, nervousness

• Numbness or tingling in hands/feet

• Muscle cramps or spasms

• Fatigue, weakness, loss of energy

• Abdominal pain, dry mouth, nausea, vomiting, diarrhea

• Infection, nasal inflammation, tension, irritability

Drug Interactions
Lozol may cause low potassium (hypokalemia) and low magnesium (hypomagnesemia), which can increase the risk of fatal arrhythmias in patients taking:

• Digoxin (Lanoxin)

• Amiodarone (Cordarone)

Also:

• Diuretics reduce lithium clearance, increasing risk of lithium toxicity

Missed Dose
If you miss a dose, skip it if it’s almost time for the next one.
Do not double the dose to make up for a missed one. Continue with your normal schedule.

Overdose
Seek emergency medical attention if you suspect an overdose. Symptoms may include:

• Nausea, vomiting

• Weakness

• Stomach pain

• Electrolyte imbalances

Storage
Store at 15–30°C (59–86°F), away from moisture and light. Keep out of reach of children.

Disclaimer
This information is provided for general reference only. It does not include all possible directions, interactions, or precautions. It should not be used for self-diagnosis or self-treatment. Always consult your healthcare provider for specific medical advice. We do not take responsibility for any consequences from using this information or from self-medication.