Generic Periactin (Cyproheptadine)

Common Use

Periactin is an antihistamine used primarily to treat allergic reactions such as hay fever, hives, and other types of seasonal or perennial allergies. It works by blocking the effects of histamine—a substance the body produces during allergic reactions. In addition to allergy relief, Periactin is also prescribed for managing symptoms associated with motion sickness, including nausea, vomiting, and dizziness. In some cases, it is used to stimulate appetite in underweight individuals and has also been applied off-label to help alleviate cluster headaches.

Dosage and Administration

It is essential to follow your physician’s exact instructions when using Periactin. Do not exceed the recommended dose. Each dose should be taken with a full glass of water, and it can be taken with or without food. For adults, the typical dose is 4 milligrams (one tablet), taken three times daily. Daily dosage generally falls between 12 to 16 milligrams, but should not exceed 32 milligrams in any 24-hour period.

For children aged 7 to 14, the recommended dose is 4 milligrams two to three times a day, with a maximum daily limit of 16 milligrams. Children aged 2 to 6 are usually prescribed 2 milligrams two or three times daily, with a daily maximum of 12 milligrams. Elderly patients are typically prescribed the lowest effective dose to minimize the risk of side effects. Always consult your doctor to determine the correct dosage and duration based on individual needs.

Precautions

Periactin may cause drowsiness or impair coordination, especially during the early days of treatment. Use caution when driving, operating machinery, or performing any activity requiring alertness. The medication should be used carefully in patients with a history of asthma, glaucoma, thyroid disorders, high blood pressure, heart disease, or circulation issues. Periactin should not be taken during pregnancy or while breastfeeding unless specifically approved by a healthcare provider. Always inform your doctor about your full medical history before beginning treatment.

Contraindications

Periactin should not be used in patients experiencing an acute asthma attack or in newborns or premature infants, as it has been associated with serious respiratory complications. It is contraindicated in individuals with known hypersensitivity to cyproheptadine or related compounds. Do not use Periactin if you are currently taking monoamine oxidase inhibitors (MAOIs), or if you have conditions such as glaucoma, peptic ulcers with obstruction, urinary retention, or prostate enlargement. It is also not recommended for elderly or frail individuals without close medical supervision.

Possible Side Effects

Serious allergic reactions such as swelling of the face or throat, difficulty breathing, or hives require immediate medical attention. Severe side effects may include confusion, hallucinations, seizures, abnormal thoughts or behavior, ringing in the ears, rapid or irregular heartbeat, excessive bruising, low urine output, jaundice, or unexplained weakness.

Milder side effects can include dizziness, drowsiness, blurred vision, dry mouth or nose, upset stomach, diarrhea, constipation, increased urination or sweating, restlessness (especially in children), sleep disturbances, tingling sensations, or changes in appetite. If any side effects persist or become severe, notify your healthcare provider promptly.

Drug Interactions

Periactin can interact with a variety of medications. It should not be taken with MAO inhibitors such as isocarboxazid, phenelzine, rasagiline, selegiline, or tranylcypromine due to the risk of serious side effects. Drug interactions do not always require discontinuation but may require dosage adjustment or special monitoring. Inform your doctor of all prescription, over-the-counter, and herbal medications you are using to avoid harmful interactions.

Missed Dose

If you miss a dose of Periactin, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and resume your usual dosing schedule. Do not take a double dose to make up for the missed one.

Overdose

An overdose of Periactin may cause symptoms such as extreme drowsiness, dry mouth, dilated pupils, confusion, hallucinations, pale skin, vomiting, or fainting. If overdose is suspected, seek immediate medical attention. Treatment may involve gastric lavage, supportive care, and close monitoring of vital functions.

Storage

Store Periactin at room temperature, ideally between 15 and 25 degrees Celsius (59–77 degrees Fahrenheit). Protect it from moisture, heat, and direct light. Keep all medications out of reach of children and pets. Do not use the medication past its expiration date.

Disclaimer

This content provides general information for educational purposes only and is not a substitute for medical advice, diagnosis, or treatment from a healthcare provider. Always consult your physician or pharmacist regarding any questions related to your medications. The creators of this content are not responsible for any damage, injury, or adverse effects resulting from the misuse of the information or the medications described.